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TCR Signal Transduction in Antigen-Specific Memory CD8 T Cells
Journal of Immunology (2003)
  • Thandi M. Onami, University of Tennessee - Knoxville
  • Ellen N. Kersh
  • Susan M. Kaech
  • Miriana Moran
  • E. John Wherry
  • M. Carrie Miceli
  • Rafi Ahmed

Memory T cells are more responsive to Ag than naive cells. To determine whether memory T cells also have more efficient TCR signaling, we compared naive, effector, and memory CD8 T cells of the same antigenic specificity. Surprisingly, initial CD3 signaling events are indistinguishable. However, memory T cells have more extensive lipid rafts with higher phosphoprotein content before TCR engagement. Upon activation in vivo, they more efficiently induce phosphorylation of-LAT (linker for activation of T cells), ERK (extracellular signal-regulated kinase), JNK (c-Jun N-terminal kinase), and p38. Thus, memory CD8 T cells do not increase their TCR sensitivity, but are better poised to augment downstream signals. We propose that this regulatory mechanism might increase signal transduction in memory T cells, while limiting TCR cross-reactivity and autoimmunity.

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Citation Information
Thandi M. Onami, Ellen N. Kersh, Susan M. Kaech, Miriana Moran, et al.. "TCR Signal Transduction in Antigen-Specific Memory CD8 T Cells" Journal of Immunology Vol. 170 Iss. 11 (2003)
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