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Article
Combinatorial Roles of the Nuclear Receptor Corepressor in Transcription and Development
Cell (2000)
  • Thandi M. Onami, University of Tennessee - Knoxville
  • Kristen Jepsen, University of California - San Diego
  • Ola Hermanson, University of California - San Diego
  • Anatoli S. Anatoli S. Gleiberman, University of California - San Diego
  • Victoria Lunyak, University of California - San Diego
  • Robert J. McEvilly, University of California - San Diego
  • Riki Kurokawa, University of California - San Diego
  • Vivek Kumar, University of California - San Diego
  • Forrest Liu, University of California - San Diego
  • Edward Seto, University of South Florida
  • Stephen M. Hedrick, University of California - San Diego
  • Gail Mandel
  • Christopher K. Glass, University of California - San Diego
  • David W. Rose, University of California - San Diego
  • Michael G. Rosenfeld, University of California - San Diego
Abstract

Transcriptional repression plays crucial roles in diverse aspects of metazoan development, implying critical regulatory roles for corepressors such as N-CoR and SMRT. Altered patterns of transcription in tissues and cells derived from N-CoR gene–deleted mice and the resulting block at specific points in CNS, erythrocyte, and thymocyte development indicated that N-CoR was a required component of short-term active repression by nuclear receptors and MAD and of a subset of long-term repression events mediated by REST/NRSF. Unexpectedly, N-CoR and a specific deacetylase were also required for transcriptional activation of one class of retinoic acid response element. Together, these findings suggest that specific combinations of corepressors and histone deacetylases mediate the gene-specific actions of DNA-bound repressors in development of multiple organ systems.

Publication Date
September, 2000
Citation Information
Thandi M. Onami, Kristen Jepsen, Ola Hermanson, Anatoli S. Anatoli S. Gleiberman, et al.. "Combinatorial Roles of the Nuclear Receptor Corepressor in Transcription and Development" Cell Vol. 102 Iss. 6 (2000)
Available at: http://works.bepress.com/thandi_onami/16/