Skip to main content
Impact of Metformin on Peak Aerobic Capacity
Applied Physiology, Nutrition, and Metabolism
  • Barry Braun, University of Massachusetts - Amherst
  • Pamela Eze, University of Massachusetts - Amherst
  • Brooke R. Stephens, University of Massachusetts - Amherst
  • Todd A. Hagobian, University of Massachusetts - Amherst
  • Carrie G. Sharoff, University of Massachusetts - Amherst
  • Stuart R. Chipkin, University of Massachusetts - Amherst
  • Benjamin Goldstein, University of Massachusetts - Amherst
Publication Date
Individually, exercise and the drug metformin have been shown to prevent or delay type 2 diabetes. Metformin mildly inhibits complex I of the electron transport system and may impact aerobic capacity in people exercising while taking metformin. The purpose of the study was to evaluate the effects of metformin on maximal aerobic capacity in healthy individuals without mitochondrial dysfunction. Seventeen healthy, normal-weight men (n=11) and women (n=6) participated in a double-blind, placebo-controlled, cross-over design. Peak aerobic capacity was measured twice using a continuous, incrementally graded protocol; once after 7-9 d of metformin (final dose=2000 mg/d) and once with placebo, with 1 week between tests. The order of the conditions was counterbalanced. Peak oxygen uptake (VO2 peak), heart rate (HR), ventilation (VE), respiratory exchange ratio (RER), rating of perceived exertion (RPE), and test duration were compared across conditions using paired t tests with the R statistical program. VO2 peak (-2.7%), peak heart rate (-2.0%), peak ventilation (-6.2%), peak RER (-3.0%), and exercise duration (-4.1%) were all reduced slightly, but significantly, with metformin (all p
Citation Information
Barry Braun, Pamela Eze, Brooke R. Stephens, Todd A. Hagobian, et al.. "Impact of Metformin on Peak Aerobic Capacity" Applied Physiology, Nutrition, and Metabolism Vol. 33 Iss. 1 (2008) p. 61 - 67
Available at: