Predicting Potential Placebo Effect in Drug Treated SubjectsThe International Journal of Biostatistics
AbstractNon-specific responses to treatment (commonly known as placebo response) are pervasive when treating mental illness. Subjects treated with an active drug may respond in part due to non-specific aspects of the treatment, i.e, those not related to the chemical effect of the drug. To determine the extent a subject responds due to the chemical effect of a drug, one must disentangle the specific drug effect from the non-specific placebo effect. This paper presents a unique statistical model that allows for the separate prediction of a specific effect and non-specific effects in drug treated subjects. Data from a clinical trial comparing fluoxetine to a placebo for treating depression is used to illustrate this methodology.
Citation InformationEva Petkova, Thaddeus Tarpey and Usha Govindarajulu. "Predicting Potential Placebo Effect in Drug Treated Subjects" The International Journal of Biostatistics Vol. 5 Iss. 1 (2009) ISSN: 1557-4679
Available at: http://works.bepress.com/thaddeus_tarpey/25/