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Article
Structure-activity relationships for flow cytometric data of smaller polycyclic aromatic hydrocarbons
SAR and QSAR in environmental research (2006)
  • B Wan
  • G S Sayler
  • Terry W Schultz, University of Tennessee - Knoxville
Abstract

Using flow cytometry, select polycyclic aromatic hydrocarbons (PAHs) were evaluated for induction of apoptosis in human monocytic THP-1 cells. Based on structure, the PAHs were divided into linear and bay-region-containing compounds. Except for fluorene, the linear PAHs failed to induce apoptosis; all of the bay-region-containing PAHs induce apoptosis. The relationship that a bay-region is required to induce apoptosis is supported by results for benzo[a]pyrene (positive) and 2-methylanthracene (negative). The data for bay-region containing, four-ringed PAH compounds reveal that possessing a linear-region of more than two rings diminishes the ability of a PAH to induce apoptosis. Owing to the steric interactions of the hydrogen atoms of the methyl group and those on the ring carbons, 1-methylanthracene does not have a true bay-region. However, the methyl group substituted in the 1-position does confer a bay-like conformation, which may explain its activity in contrast to its parent derivative anthracene and its 2-postion homologue.

Publication Date
2006
Citation Information
B Wan, G S Sayler and Terry W Schultz. "Structure-activity relationships for flow cytometric data of smaller polycyclic aromatic hydrocarbons" SAR and QSAR in environmental research Vol. 17 Iss. 6 (2006)
Available at: http://works.bepress.com/terry_schultz/20/