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Article
Structure-activity relationships for osteolathyrism: I. Effects of altering the semicarbazide structure.
Transactions of the American Microscopical Society (1988)
  • Terry W Schultz, University of Tennessee - Knoxville
  • T.S. Ranney
  • G.W. Riggin
  • M. Cajina-Quezada
Abstract

The toxic and osteolathyrogenic effects of 15 chemicals reflecting modifications of semicarbazide [H2N-N(H)-C(=O)-NH2] were evaluated using the Frog Embryo Teratogenesis Assay: Xenopus (FETAX). Osteolathyrism, the failure of connective tissue fibers to cross-link correctly, is expressed as gross alterations in the long axis of the embryo and a sinusoidal configuration of the notochord. Alteration (addition or subtraction) at the hydrazino (H2NNH-) end of the molecule sharply reduces osteolathyrogenic activity. Alteration at the amino (H2N-) end of the molecule results in a graded response. The replacement of oxygen with sulfur causes no loss of osteolathyrogenic activity.

Publication Date
1988
Citation Information
Terry W Schultz, T.S. Ranney, G.W. Riggin and M. Cajina-Quezada. "Structure-activity relationships for osteolathyrism: I. Effects of altering the semicarbazide structure." Transactions of the American Microscopical Society Vol. 107 Iss. 2 (1988)
Available at: http://works.bepress.com/terry_schultz/176/