Skip to main content
Article
Structure-activity relationships of selected pyridines. III. Log Kow analysis
Ecotoxicology and environmental safety (1987)
  • Terry W Schultz, University of Tennessee - Knoxville
  • F M Applehans
  • G W Riggin
Abstract

Twenty 2- and 3-position derivatives of pyridine (C5H5N) were tested following a short-term static protocol. Biological activity was monitored as population growth of Tetrahymena pyriformis. These data were combined with previously reported data for twenty 4-position derivatives. Structure-activity relationships were examined using Kow as the physicochemical descriptor. These data form three linear models: one for the non-H-polar derivatives and two for the H-polar derivatives. The latter two models are parallel but have no obvious basis for a priori selectivity. HPLC analysis for toxicant persistence shows that only the smaller non-H-polar derivatives have any significant abiotic loss over the duration of the biological testing.

Publication Date
February, 1987
Citation Information
Terry W Schultz, F M Applehans and G W Riggin. "Structure-activity relationships of selected pyridines. III. Log Kow analysis" Ecotoxicology and environmental safety Vol. 13 Iss. 1 (1987)
Available at: http://works.bepress.com/terry_schultz/130/