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Predicted toxicities of aryl alkanols and related compounds
Journal of applied toxicology (1993)
  • Terry W Schultz, University of Tennessee - Knoxville
  • D T Lin
  • R W Culberson

The relative toxicity of selected aryl and/or alkyl alcohols was evaluated in the batch culture Tetrahymena pyriformis population-growth impairment assay. Chemicals evaluated included normal and branched primary alcohols with mono-, bi- or diaromatic substituents as well as aryl-substituted ethers. Log 1-octanol/water partition coefficients (log Kow) along with previously developed quantitative structure-activity relationships (QSARs) for both the non-polar narcosis and polar narcosis mechanism of action were used to predict relative toxicity. Observed and predicted toxicities measured as log IGC50(-1) were compared. All phenols and naphthyl-substituted compounds, as well as the biphenyl methanols, benzhydrols and 1,1-diphenylethanol, model more accurately as polar narcotics. Both monoaromatic- and diaromatic-substituted branched arylalkyl alcohols, as well as monoaromatic ethers, model best as non-polar narcotics. The C1-C6 straight-chain aryl alkanols, as well as 3-phenyl-1-butanol, model intermediately between non-polar and polar narcosis. The triaromatic-substituted alcohol was not toxic at saturation. These findings are consistent with the idea that narcosis, the reversible state of arrested bioactivity, is a series of mechanisms.

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Citation Information
Terry W Schultz, D T Lin and R W Culberson. "Predicted toxicities of aryl alkanols and related compounds" Journal of applied toxicology Vol. 13 Iss. 6 (1993)
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