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Fish oil supplementation in the treatment of major depression: A randomised double-blind placebo-controlled trial
Faculty of Health and Behavioural Sciences - Papers (Archive)
  • B. F. S. Grenyer, University of Wollongong
  • Trevor P Crowe, University of Wollongong
  • Barbara Meyer, University of Wollongong
  • Alice Owen
  • Elizabeth Grigonis-Deane
  • Peter Caputi, University of Wollongong
  • Peter Howe
RIS ID
19889
Publication Date
1-1-2007
Publication Details

Grenyer, BFS, Crowe, TP, Meyer, B, Owen, A, Grigonis-Deane, E, Caputi, P & Howe, P, Fish oil supplementation in the treatment of major depression: A randomised double-blind placebo-controlled trial, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 31, 2007, p 1393-1396.

Abstract

Dietary deficiencies in essential omega-3 polyunsaturated fatty acids derived from fish are associated with depression and some fish oils may have therapeutic benefits. We aimed to determine whether taking tuna fish oil confers any additional benefit to conventional outpatient treatment for major depression. A randomized double-blind placebo-controlled four-month trial comparing tuna fish oil versus placebo was conducted on 83 outpatients with major depression. Despite large reductions in depression there were no significant differences at any assessment time point between patients receiving fish oil compared to placebo. Red blood cell incorporation of fatty acids indicated good compliance with oil supplementation, although this sample was not initially deficient in omega-3s. This particular dose and type of fish oil conferred no additional benefit to conventional treatment of depression in this sample. Future studies could target participants with pre-existing omega-3 deficiency and appraise alternate enriched types and higher doses of omega-3 supplementation.

Citation Information
B. F. S. Grenyer, Trevor P Crowe, Barbara Meyer, Alice Owen, et al.. "Fish oil supplementation in the treatment of major depression: A randomised double-blind placebo-controlled trial" (2007) p. 1393 - 1396
Available at: http://works.bepress.com/tcrowe/11/