Although the stress and socialization literatures have flourished over the past several decades, they have done so largely independently, and our understanding of the cost of stress to organizations in the form of newcomer turnover, lowered adjustment, and the health and well-being of newcomers is largely unknown. This review takes an explicitly newcomer-centric perspective toward the socialization process by examining newcomer experiences through the lens of popular models of work stress, including the job demands-resources model, the transactional theory of stress, and the challenge-hindrance stressor framework. In doing so, we identify individual and work-related factors that contribute to the experience of stress for newcomers and point to ways in which organizational and employee-driven inputs can assist in building and acquiring important resources needed to cope with the demands faced in a new work role. In addition, we offer a framework that incorporates individual experiences and behaviors as they relate to newcomer stress in the context of socialization. This framework delineates the newcomer stress appraisal process and describes the impact these appraisals have on the experience of stress or engagement for new employees as well as the behaviors that can be expected in reaction to those states. Through this process, our review highlights natural points for integration between stress and socialization research and identifies potential areas for future investigation that leverage understanding of work stress to expand socialization theory and practice.