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Article
Excretion of 14C-Fumonisin B1, 14C-Hydrolyzed Fumonisin B1, and 14C-Fumonisin B1-Fructose in Rats
Journal of Agricultural and Food Chemistry
  • William R. Dantzer, Iowa State University
  • Joan Hopper, Iowa State University
  • Kathleen Mullin, Iowa State University
  • Suzanne Hendrich, Iowa State University
  • Patricia A. Murphy, Iowa State University
Document Type
Article
Publication Date
9-14-1999
DOI
10.1021/jf981340v
Abstract
14C-Fumonisin B1 (FB1) was produced by Fusarium proliferatum M-5991 in modified Myro liquid medium and purified to >95% purity with a specific activity of 1.7 mCi/mmol. Nine male and nine female F344/N rats were each dosed by gavage with 0.69 μmol of 14C-FB1, 14C-hydrolyzed FB1, or 14C-FB1-fructose/kg body weight. Urinary excretion of 14C-FB1 and 14C-FB1-fructose was 0.5% and 4.4% of the total dose, respectively, and was similar between male and female rats. Urinary excretion of 14C-hydrolyzed HFB1 was significantly greater (P > 0.05) in female rats as compared with male rats (17.3% vs 12.8% of the total dose, respectively). There were no significant (P > 0.05) differences in biliary excretion of the three fumonisin compounds with a mean of 1.4% of the dose excreted at 4 h after dosing. Lesser amounts continued to be excreted up to 9.25 h after dosing. Although biliary excretion of the14C-FB1, 14C-hydrolyzed FB1, and 14C-FB1-fructose was similar, increased urinary excretion of the 14C-hydrolyzed FB1 as compared to 14C-FB1 and 14C-FB1-fructose indicated a greater absorption of the hydrolyzed form.
Comments

Reprinted with permission from Journal of Agricultural and Food Chemistry, 47(10):4291-4296. doi: 10.1021/jf981340v. Copyright 1999 American Chemical Society.

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One-time permission is granted only for the use specified in your request. No additional uses are granted (such as derivative works or other editions).
Copyright Owner
American Chemical Society
Language
en
Date Available
2014-11-14
File Format
application/pdf
Citation Information
William R. Dantzer, Joan Hopper, Kathleen Mullin, Suzanne Hendrich, et al.. "Excretion of 14C-Fumonisin B1, 14C-Hydrolyzed Fumonisin B1, and 14C-Fumonisin B1-Fructose in Rats" Journal of Agricultural and Food Chemistry Vol. 47 Iss. 10 (1999) p. 4291 - 4296
Available at: http://works.bepress.com/suzanne_hendrich/8/