Skip to main content
Article
Efficacy of a Mycotoxin Binder against Dietary Fumonisin, Deoxynivalenol, and Zearalenone in Rats
Journal of Agricultural and Food Chemistry
  • Qiang Zhang, Iowa State University
  • My Truong, Kemin Nutrisurance,
  • Koen Meynen, Kemin Nutrisurance
  • Patricia A. Murphy, Iowa State University
  • Suzanne Hendrich, Iowa State University
Document Type
Article
Publication Date
6-8-2011
DOI
10.1021/jf202042z
Abstract
It was hypothesized that a mycotoxin binder, Grainsure E, would inhibit adverse effects of a mixture of fumonisin B1, deoxynivalenol, and zearalenone in rats. For 14 and 28 days, 8–10 Sprague–Dawley rats were fed control diet, Grainsure E (0.5%), toxins (7 μg fumonisin B1/g, 8 μg of deoxynivalenol/g and 0.2 μg of zearalenone/g), toxins (12 μg of fumonisin B1/g, 9 μg of deoxynivalenol/g, and 0.2 μg of zearalenone/g + Grainsure E), or pair-fed to control for food intake of toxin-fed rats. After 28 days, decreased body weight gain was prevented by Grainsure E in toxin-fed female rats, indicating partial protection against deoxynivalenol and fumonisin B1. Two effects of fumonisin B1 were partly prevented by Grainsure E in toxin-fed rats, increased plasma alanine transaminase (ALT) and urinary sphinganine/sphingosine, but sphinganine/sphingosine increase was not prevented in females at the latter time point. Grainsure E prevented some effects of fumonisin B1 and deoxynivalenol in rats.
Comments

Reprinted with permission from Journal of Agricultural and Food Chemistry, 59(13)2011:7527-7533. doi: 10.1021/jf202042z. Copyright 2011 American Chemical Society.

Rights
One-time permission is granted only for the use specified in your request. No additional uses are granted (such as derivative works or other editions.).
Copyright Owner
American Chemical Society
Language
en
Date Available
2014-11-13
File Format
application/pdf
Citation Information
Qiang Zhang, My Truong, Koen Meynen, Patricia A. Murphy, et al.. "Efficacy of a Mycotoxin Binder against Dietary Fumonisin, Deoxynivalenol, and Zearalenone in Rats" Journal of Agricultural and Food Chemistry Vol. 59 Iss. 13 (2011) p. 7527 - 7533
Available at: http://works.bepress.com/suzanne_hendrich/7/