Article
Inhibition of Azoxymethane-Induced Preneoplastic Lesions in the Rat Colon by a Cooked Stearic Acid Complexed High-Amylose Cornstarch
Journal of Agricultural and Food Chemistry
Document Type
Article
Disciplines
Publication Date
1-1-2011
DOI
10.1021/jf202002c
Abstract
This study evaluated a novel stearic acid complexed high-amylose cornstarch (SAC) for the prevention of preneoplastic lesions in the colon of azoxymethane (AOM)-treated Fisher 344 rats fed resistant starches at 50–55% of the diet for 8 weeks. Uncooked SAC (r-SAC) diet was compared with raw normal-cornstarch diet (r-CS) or raw high-amylose cornstarch diet (r-HA), and water-boiled CS (w-CS) was compared with w-HA and w-SAC, respectively. w-SAC markedly reduced mucin-depleted foci (MDF) numbers compared with w-HA or w-CS. r-HA significantly decreased aberrant crypt foci (ACF) numbers compared with r-CS or r-SAC. Increased cecum weight and decreased cecum pH were observed in the SAC or HA groups. The highest amounts of total or individual short-chain fatty acids (SCFAs) in cecum and of butyrate or propionate in feces were observed in the AOM-treated w-SAC group. This study revealed the effectiveness of a novel resistant starch in inhibiting colonic preneoplastic lesions and the importance of high-moisture cooking on the suppression of colon carcinogenesis by this resistant starch.
Copyright Owner
American Chemical Society
Copyright Date
2011
Language
en
File Format
application/pdf
Citation Information
Yinsheng Zhao, Jovin Hasjim, Li Li, Jay-Lin Jane, et al.. "Inhibition of Azoxymethane-Induced Preneoplastic Lesions in the Rat Colon by a Cooked Stearic Acid Complexed High-Amylose Cornstarch" Journal of Agricultural and Food Chemistry Vol. 59 Iss. 17 (2011) p. 9700 - 9708 Available at: http://works.bepress.com/suzanne_hendrich/5/
Posted with permission from Journal of Agricultural and Food Chemistry 59, no. 17 (2011): 9700–9708, doi:10.1021/jf202002c. Copyright 2011 American Chemical Society.