Reaction with Fructose Detoxifies Fumonisin B1 while Stimulating Liver-Associated Natural Killer Cell Activity in RatsJournal of Agricultural and Food Chemistry
AbstractFumonisin B1 (FB1) was reacted with fructose in an attempt to detoxify this mycotoxin. Fischer 344/N rats were initiated with diethylnitrosamine (15 mg/kg body weight) and then fed 69.3 μmol FB1/kg diet or 69.3 μmol FB1 reacted with fructose (FB1−fructose)/kg diet for 4 weeks. In comparison with the rats fed basal diet or FB1−fructose, the FB1-fed rats had significantly increased plasma cholesterol (P < 0.01), plasma alanine aminotransferase activity (P < 0.05), and endogenous hepatic prostaglandin production (P < 0.05). Placental glutathione S-transferase-positive and γ-glutamyl transferase-positive altered hepatic foci occurred only in the FB1-fed rats. Liver-associated natural killer (NK) cell activity was significantly decreased in the FB1-fed rats and increased in the group fed FB1-fructose, as compared with the basal group (P < 0.03). Therefore, modifying FB1 with fructose seems to prevent FB1-induced hepatotoxicity and promotion of hepatocarcinogenesis while stimulating liver-associated NK cell activity in rats.
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Copyright OwnerAmerican Chemical Society
Citation InformationZ. Lu, W. R. Dantzer, E. C. Hopmans, V. Prisk, et al.. "Reaction with Fructose Detoxifies Fumonisin B1 while Stimulating Liver-Associated Natural Killer Cell Activity in Rats" Journal of Agricultural and Food Chemistry Vol. 45 Iss. 3 (1997) p. 803 - 809
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