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Article
Toxicity of Fusarium proliferatum-fermented nixtamalized corn-based diets fed to rats: Effect of nutritional status
Journal of Agricultural and Food Chemistry
  • Suzanne Hendrich, Iowa State University
  • Kathrine A. Miller, Iowa State University
  • Terrance M. Wilson, Iowa State University
  • Patricia A. Murphy, Iowa State University
Document Type
Article
Publication Date
10-1-1993
DOI
10.1021/jf00034a025
Abstract

Male F344/ N rats were fed corn, nixtamalized corn, Fusarium proli feratum- fermented (FP) corn to provide 50 mg/kg fumonisin B1 (FB1), or nixtamalized FP corn (NFP), with and without supplemented nutrients. Nixtamalization of FP corn almost completely hydrolyzed FB1 and produced 7-10 mg/kg hydrolyzed fumonisin (HFB1). Relative liver weight was significantly increased in nutrient-supplemented rats fed FP or NFP corn. Plasma cholesterol increased in rats fed FP or NFP corn. Plasma glutamate­ pyruvate transaminase was elevated in allrats fed FP corn and in nutrient-supplemented rats fed NFP corn. All rats fed FP corn and nutrient-supplemented rats fed NFP corn exhibited hepatocellular adenomas, whereas unsupplemented rats fed NFP corn had few adenomas. HFB1 and other uncharacterized F. proli feratum mycotoxins produced by nixtamalization were less toxic than were toxicants, including FB1, present in FP corn. Improvement in nutritional status due to nixtamalization stimulated NFP corn toxicity.

Comments

Reprinted with permission from Journal of Agricultural and Food Chemistry. 41(10):1649-1654. doi: 10.1021/jf00034a025. Copyright 1993 American Chemical Society.

Rights
One-time permission is granted only for the use specified in your request. No additional uses are granted (such as derivative works or other editions).
Copyright Owner
American Chemical Society
Language
en
Date Available
2014-11-18
File Format
application/pdf
Citation Information
Suzanne Hendrich, Kathrine A. Miller, Terrance M. Wilson and Patricia A. Murphy. "Toxicity of Fusarium proliferatum-fermented nixtamalized corn-based diets fed to rats: Effect of nutritional status" Journal of Agricultural and Food Chemistry Vol. 41 Iss. 10 (1993) p. 1649 - 1654
Available at: http://works.bepress.com/suzanne_hendrich/27/