Glucose Reaction with Fumonisin B1 Partially Reduces Its Toxicity in SwineJournal of Agricultural and Food Chemistry
AbstractAcute and subacute intraperitoneal doses of fumonisin B1 (FB1) were administered to test the efficacy of the FB1-glucose reaction products in detoxifying FB1 in swine. In the acute study at 11 µmol of FB1/kg of body weight, five of six pigs administered FB1 and four of six pigs administered FB1- glucose died from acute pulmonary edema. Analysis of weight gain, serum aspartate aminotransferase and γ-glutamyltransferase, total cholesterol, and pathological evaluation did not provide evidence of protection against FB1 toxicity by the FB1-glucose reaction products. In the subacute study at 5.5 µmol of FB1/kg of body weight, one pig administered FB1 died from liver damage. Analysis of serum aspartate aminotransferase, γ-glutamyltransferase, and total bilirubin showed protection against FB1 toxicity by the FB1-glucose reaction products. The levels of sphinganine and sphinganine/sphingosine ratios in serum and liver as well as pathologic findings provided definitive evidence of protection against the FB1 toxic effects by this detoxification procedure (p < 0.05).
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Copyright OwnerAmerican Chemical Society
Citation InformationGuillermo Fernandez-Surumay, Gary D. Osweiler, Michael Yaeger, Catherine C. Hauck, et al.. "Glucose Reaction with Fumonisin B1 Partially Reduces Its Toxicity in Swine" Journal of Agricultural and Food Chemistry Vol. 52 Iss. 25 (2004) p. 7732 - 7739
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