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Isoflavone Glycitein Diminished Plasma Cholesterol in Female Golden Syrian Hamsters
Journal of Agricultural and Food Chemistry
  • Sun-Ok Lee, Iowa State University
  • Mathieu Renouf, Iowa State University
  • Zhong Ye, Iowa State University
  • Patricia A. Murphy, Iowa State University
  • Suzanne Hendrich, Iowa State University
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The soybean isoflavones, daidzein, genistein, and glycitein, were hypothesized to act as cholesterol- lowering components, separate from soy protein. Pure synthetic daidzein, genistein, or glycitein (0.9 mmol/kg diet) or a casein-based control diet was fed to groups of 10 female Golden Syrian hamsters for 4 weeks. Hamsters fed glycitein had significantly lower plasma total (by 15%) and non-HDL (by 24%) cholesterol compared with those fed casein (P < 0.05). Daidzein and genistein’s effects on these lipids did not differ from the effects of either casein or glycitein. Plasma HDL cholesterol and triglyceride concentrations were not significantly affected by dietary treatments. The percentage of urinary recovery of the ingested dose of each isoflavone was glycitein > daidzein > genistein (33.2%, 4.6%, 2.2%, respectively), with the apparent absorption of glycitein significantly greater than that of the other isoflavones. These data suggest that glycitein’s greater cholesterol-lowering effect was due to its greater bioavailability, as reflected in its urinary recovery compared with that of the other isoflavones.

Reprinted with permission from Journal of Agricultural and Food Chemistry , 55(26):11063-11067. doi: 10.1021/jf070972r . Copyright 2007 American Chemical Society.

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American Chemical Society
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Sun-Ok Lee, Mathieu Renouf, Zhong Ye, Patricia A. Murphy, et al.. "Isoflavone Glycitein Diminished Plasma Cholesterol in Female Golden Syrian Hamsters" Journal of Agricultural and Food Chemistry Vol. 55 Iss. 26 (2007) p. 11063 - 11067
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