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Fumonisin B-Glucose Reaction Products Are Less Toxic When Fed to Swine
Journal of Agricultural and Food Chemistry
  • Guillermo Fernandez-Surumay, Iowa State University
  • Gary D. Osweiler, Iowa State University
  • Michael J. Yaeger, Iowa State University
  • George E. Rottinghaus, University of Missouri
  • Suzanne Hendrich, Iowa State University
  • Lucas K. Buckley, Iowa State University
  • Patricia A. Murphy, Iowa State University
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The effects of fumonisin B-glucose reaction products in swine diets was examined. Pigs were fed diets containing 528 µmol of total fumonisin B/kg (FB), 528 µmol of total FB-glucose adducts/kg (FB-G, 122 µmol of unreacted FB/kg), or 0 µmol of total FB/kg for 15 days to test the efficacy of the FB-G reaction products in detoxifying FB. Weight gain in FB pigs was lower than in FB-G or controls, which was correlated with feed intake reduction in FB pigs. Serum aspartate aminotransferase, γ-glutamyltransferase, and total bilirubin in FB pigs were higher than in FB-G or control pigs. Serum sphinganine/shingosine ratios in FB pigs were higher than in FB-G or control pigs. Microscopic examination of tissues from FB pigs showed generalized liver necrosis and apoptosis with marked cellular pleomorphism and disorganized hepatic cords. The liver and kidneys in the FB-G group appeared to be normal. Tissues of controls were free of lesions. Results suggest that dietary FB-G products are less toxic to swine and may provide an detoxification approach in instances of widespread FB grain contamination (p < 0.05).

Reprinted with permission from Journal of Agricultural and Food Chemistry, 53(10):4264-4271. doi: 10.1021/jf0500076. Copyright 2005 American Chemical Society.

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American Chemical Society
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Guillermo Fernandez-Surumay, Gary D. Osweiler, Michael J. Yaeger, George E. Rottinghaus, et al.. "Fumonisin B-Glucose Reaction Products Are Less Toxic When Fed to Swine" Journal of Agricultural and Food Chemistry Vol. 53 Iss. 10 (2005) p. 4264 - 4271
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