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Article
Fumonisin B-Glucose Reaction Products Are Less Toxic When Fed to Swine
Journal of Agricultural and Food Chemistry
  • Guillermo Fernandez-Surumay, Iowa State University
  • Gary D. Osweiler, Iowa State University
  • Michael J. Yaeger, Iowa State University
  • George E. Rottinghaus, University of Missouri
  • Suzanne Hendrich, Iowa State University
  • Lucas K. Buckley, Iowa State University
  • Patricia A. Murphy, Iowa State University
Document Type
Article
Publication Date
4-16-2005
DOI
10.1021/jf0500076
Abstract

The effects of fumonisin B-glucose reaction products in swine diets was examined. Pigs were fed diets containing 528 µmol of total fumonisin B/kg (FB), 528 µmol of total FB-glucose adducts/kg (FB-G, 122 µmol of unreacted FB/kg), or 0 µmol of total FB/kg for 15 days to test the efficacy of the FB-G reaction products in detoxifying FB. Weight gain in FB pigs was lower than in FB-G or controls, which was correlated with feed intake reduction in FB pigs. Serum aspartate aminotransferase, γ-glutamyltransferase, and total bilirubin in FB pigs were higher than in FB-G or control pigs. Serum sphinganine/shingosine ratios in FB pigs were higher than in FB-G or control pigs. Microscopic examination of tissues from FB pigs showed generalized liver necrosis and apoptosis with marked cellular pleomorphism and disorganized hepatic cords. The liver and kidneys in the FB-G group appeared to be normal. Tissues of controls were free of lesions. Results suggest that dietary FB-G products are less toxic to swine and may provide an detoxification approach in instances of widespread FB grain contamination (p < 0.05).

Comments

Reprinted with permission from Journal of Agricultural and Food Chemistry, 53(10):4264-4271. doi: 10.1021/jf0500076. Copyright 2005 American Chemical Society.

Rights
One-time permission is granted only for the use specified in your request. No additional uses are granted (such as derivative works or other editions).
Copyright Owner
American Chemical Society
Language
en
Date Available
2014-11-14
File Format
application/pdf
Citation Information
Guillermo Fernandez-Surumay, Gary D. Osweiler, Michael J. Yaeger, George E. Rottinghaus, et al.. "Fumonisin B-Glucose Reaction Products Are Less Toxic When Fed to Swine" Journal of Agricultural and Food Chemistry Vol. 53 Iss. 10 (2005) p. 4264 - 4271
Available at: http://works.bepress.com/suzanne_hendrich/15/