Skip to main content
Article
Excretion of Fumonisin B1, Hydrolyzed Fumonisin B1, and the Fumonisin B1−Fructose Adduct in Rats
Journal of Agricultural and Food Chemistry
  • Ellen C. Hopmans, Iowa State University
  • Catherine C. Hauck, Iowa State University
  • Suzanne Hendrich, Iowa State University
  • Patricia A. Murphy, Iowa State University
Document Type
Article
Publication Date
7-16-1997
DOI
10.1021/jf960886j
Abstract
The excretion of fumonisin B1 (FB1), hydrolyzed FB1 (HFB1), and FB1−fructose addition products (FB1−fructose) was determined in male Fisher 344/NHsd rats. Rats were dosed by gavage with 0.69, 6.93, or 69.3 μmol/kg of body weight FB1, HFB1, or FB1−fructose. Excretion of unchanged FB1, HFB1, and HFB1 after hydrolysis was determined in urine and feces by analytical reverse phase HPLC and fluorometric detection of the o-phthaldialdehyde derivatives. Average total FB1 backbone excretion in feces was 101, 76, and 50% of the dose for FB1, HFB1, and FB1−fructose, respectively. No effect of dose level was found on the percentage of the dose excreted as total FB1 after hydrolysis. FB1−fructose appears to be absorbed to the highest extent, followed by HFB1. FB1 appears to be excreted nearly completely in the feces. The greater absorption of HFB1 may explain the greater toxicity of HFB1 compared to FB1 on a molar basis. However, the detoxification of FB1 by formation of the fructose adduct cannot be explained by reduced absorption. Average total FB1 backbone excretion in urine was 2.7, 5.0, and 5.3% of the dose for FB1, HFB1, or FB1−fructose, respectively.
Comments

Reprinted with permission from Journal of Agricultural and Food Chemistry, 45(7):2618-2625. doi: 10.1021/jf960886j. Copyright 1997 American Chemical Society.

Rights
One-time permission is granted only for the use specified in your request. No additional uses are granted (such as derivative works or other editions).
Copyright Owner
American Chemical Society
Language
en
File Format
application/pdf
Citation Information
Ellen C. Hopmans, Catherine C. Hauck, Suzanne Hendrich and Patricia A. Murphy. "Excretion of Fumonisin B1, Hydrolyzed Fumonisin B1, and the Fumonisin B1−Fructose Adduct in Rats" Journal of Agricultural and Food Chemistry Vol. 45 Iss. 7 (1997) p. 2618 - 2625
Available at: http://works.bepress.com/suzanne_hendrich/14/