Job satisfaction for social workers in health care and hospice settings is a key component for maintaining social workers in their employment. Hospice social workers have been found to have the lowest level of job satisfaction compared to other hospice professionals. The purpose of this study was to examine how relationships with co-workers, along with perceptions of hospice leadership, may be associated with hospice social workers’ job satisfaction. This was an exploratory cross sectional study. Data came from 203 hospice social workers that participated in a web-based survey and utilized the Interdependence in Interdisciplinary Collaboration Subscale and the Essential Servant Leadership Scale to measure these relationships and job satisfaction. Results indicated that interdependence and perception of servant leadership were positively associated with job satisfaction, while also showing very little changes based on other characteristics such as profit status of the hospice, caseload size and other individual and hospice characteristics.