Skip to main content
Unpublished Paper
Different Genetic Resistance Resulted in Distinct Response to Newcastle Disease Virus
Animal Industry Report
  • Jibin Zhang, Iowa State University
  • Michael G. Kaiser, Iowa State University
  • Melissa S. Herrmann, Iowa State University
  • Rodrigo A. Gallardo, University of California, Davis
  • David A. Bunn, University of California, Davis
  • Terra R. Kelly, University of California, Davis
  • Jack C. M. Dekkers, Iowa State University
  • Huaijun Zhou, Iowa State University
  • Susan J. Lamont, Iowa State University
Extension Number
ASL R3178
Publication Date
Summary and Implications

As one of the most severe infectious diseases in the poultry industry, Newcastle disease (ND) causesa significant economic loss worldwideeven with the extensive implementation of vaccine. Tofind targets to improvegenetic resistance to NDto enhanceprotection in chickens, gene expression was analyzedin spleen of two chickenlines which differed in their resistanceto ND. The comparison of gene expression between two treatments(challenged or non-challenged)inthe two chicken lines at 2 and 6 days post-inoculation (dpi) suggeststhat thatt he mostdramatic changes ofgene expression occurredin Leghorn chickens at 2dpi.Theidentifieddifferentially expressed genesthat regulatesplenicresponse toNDVprovidepotential avenuestobreedNDV-resistantchickens in the future.

Copyright Holder
Iowa State University
Citation Information
Jibin Zhang, Michael G. Kaiser, Melissa S. Herrmann, Rodrigo A. Gallardo, et al.. "Different Genetic Resistance Resulted in Distinct Response to Newcastle Disease Virus" (2017)
Available at: