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Article
Genetic Resistance to Fowl Cholera Is Linked to the Major Histocompatibility Complex
Immunogenetics
  • Susan J. Lamont, Iowa State University
  • Carole Bolin, United States Department of Agriculture
  • Norman Cheville, United States Department of Agriculture
Document Type
Article
Publication Version
Published Version
Publication Date
5-1-1987
DOI
10.1007/BF00404420
Abstract
Chickens of the Iowa State S1 line have been selected for ability to regress Rous sarcoma virus-induced (RSV) tumors, humoral immune response to GAT (Ir-GAT), and erythrocyte antigen B. Sublines homozygous at the major histocompatibility complex (MHC), as well as F1 heterozygotes and F2 segregants, were tested for resistance to fowl cholera by challenge with Pasteurella multocida strain X73. Control of the response at high doses was associated in a preliminary study with Ir-GAT and response to RSV tumors. Genetic control of resistance to low doses of P. multocida was demonstrated via sublines and F2 segregants to be linked with genes of the B-Gregion. Thus, genetic control of resistance to fowl cholera in chickens after exposure to Pasteurella multocida was shown to be linked to the major histocompatibility B complex, in this first demonstration of MHC-linked resistance to bacterial disease challenge.
Comments

This article is from Immunogenetics 25 (1987): 284, doi:10.1007/BF00404420.

Rights
Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.
Language
en
File Format
application/pdf
Citation Information
Susan J. Lamont, Carole Bolin and Norman Cheville. "Genetic Resistance to Fowl Cholera Is Linked to the Major Histocompatibility Complex" Immunogenetics Vol. 25 Iss. 5 (1987) p. 284 - 289
Available at: http://works.bepress.com/susan_lamont/80/