Skip to main content
Article
Associations of Myostatin Gene Polymorphisms with Performance and Mortality Traits in Broiler Chickens
Genetics Selection Evolution
  • Xianghai Ye, Iowa State University
  • Stewart R. Brown, Aviagen Limited
  • Kátia Nones, University of São Paulo
  • Luiz L. Coutinho, University of São Paulo
  • Jack C. Dekkers, Iowa State University
  • Susan J. Lamont, Iowa State University
Document Type
Article
Publication Version
Published Version
Publication Date
1-1-2007
DOI
10.1051/gse:2006029
Abstract
Myostatin is a negative regulator of skeletal muscle growth. We evaluated effects of myostatin polymorphisms in three elite commercial broiler chicken lines on mortality, growth, feed conversion efficiency, ultrasound breast depth, breast percentage, eviscerated carcass weight, leg defects, blood oxygen level, and hen antibody titer to infectious bursal disease virus vaccine. Progeny mean data adjusted for fixed and mate effects and DNA from 100 sires per line were used. Single nucleotide polymorphisms (SNPs) of the myostatin gene segregating in these lines were identified by designing specific primers, amplifying individual DNA in each line by polymerase chain reaction, cloning, sequencing and aligning the corresponding products. Individual sires were genotyped for five identified SNPs which contributed to eight haplotypes. Frequencies of SNP alleles and haplotypes differed between lines. Using the allele substitution effect model, the myostatin SNPs were found to have significant ( P < 0.031) associations with growth, mortality, blood oxygen and hen antibody titer to infectious bursal disease virus vaccine, although the associations were not often consistent across lines. These results suggest that the myostatin gene has pleiotropic effects on broiler performance.
Comments

This article is from Genetics Selection Evolution 39 (2007): 73, doi:10.1051/gse:2006029. Posted with permission.

Rights
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Copyright Owner
Xianghai Ye, et al
Language
en
File Format
application/pdf
Citation Information
Xianghai Ye, Stewart R. Brown, Kátia Nones, Luiz L. Coutinho, et al.. "Associations of Myostatin Gene Polymorphisms with Performance and Mortality Traits in Broiler Chickens" Genetics Selection Evolution Vol. 39 Iss. 1 (2007) p. 73 - 89
Available at: http://works.bepress.com/susan_lamont/75/