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A Genetic Variation Map for Chicken with 2.8 Million Single-Nucleotide Polymorphisms
Nature
  • Gane Ka-Shu Wong, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Bin Liu, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Jun Wang, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Yong Zhang, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Xu Yang, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Zengjin Zhang, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Qingshun Meng, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Jun Zhou, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Dawei Li, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Jingjing Zhang, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Peixiang Ni, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Songgang Li, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Longhua Ran, Beijing North Computation Center
  • Heng Li, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Jianguo Zhang, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Ruiqiang Li, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Shengting Li, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Hongkun Zheng, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Wei Lin, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Guangyuan Li, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Xiaoling Wang, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Wenming Zhao, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Jun Li, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Chen Ye, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Mingtao Dai, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Jue Ruan, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Yan Zhou, James D. Watson Institute of Genome Sciences of Zhejiang University
  • Yuanzhe Li, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Ximiao He, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Yunze Zhang, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Jing Wang, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Xiangang Huang, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Wei Tong, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Jie Chen, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Jia Ye, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Chen Chen, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Ning Wei, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Guoqing Li, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Le Dong, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Fengdi Land, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Yongqiao Sun, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Zhenpeng Zhang, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Zheng Yang, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Yingpu Yu, James D. Watson Institute of Genome Sciences of Zhejiang University
  • Yanqing Huang, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Dandan He, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Yan Xi, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Dong Wei, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Qiuhui Qi, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Wenjie Li, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Jianping Shi, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Miaoheng Wang, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Fei Xie, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Jianjun Wang, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Xiaowei Zhang, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Pei Wang, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Yiqiang Zhao, China Agricultural University
  • Ning Li, China Agricultural University
  • Ning Yang, China Agricultural University
  • Wei Dong, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Songnian Hu, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Changqing Zeng, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Weimou Zheng, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Bailin Hao, Beijing Institute of Genomics of Chinese Academy of Sciences
  • LaDeana W. Hillier, Washington University School of Medicine
  • Shiaw-Pyng Yang, Washington University School of Medicine
  • Wesley C. Warren, Washington University School of Medicine
  • Richard K. Wilson, Washington University School of Medicine
  • Mikael Brandstrom, Uppsala University
  • Hans Ellegren, Uppsala University
  • Richard P. M. A. Crooijmans, Wageningen University
  • Jan J. van der Poel, Wageningen University
  • Henk Bovenhuis, Wageningen University
  • Martien A. M. Groenen, Wageningen University
  • Ivan Ovcharenko, Lawrence Livermore National Laboratory
  • Laurie Gordon, Lawrence Livermore National Laboratory
  • Lisa Stubbs, Lawrence Livermore National Laboratory
  • Susan Lucas, United States Department of Energy Joint Genome Institute
  • Tijana Glavina, United States Department of Energy Joint Genome Institute
  • Andrea Aerts, United States Department of Energy Joint Genome Institute
  • Pete Kaiser, Institute for Animal Health
  • Lisa Rothwell, Institute for Animal Health
  • John R. Young, Institute for Animal Health
  • Sally Rogers, Institute for Animal Health
  • Brian A. Walker, Institute for Animal Health
  • Andy van Hateren, Institute for Animal Health
  • Jim Kaufman, Institute for Animal Health
  • Nat Bumstead, Institute for Animal Health
  • Susan J. Lamont, Iowa State University
  • Huaijun Zhou, Iowa State University
  • Paul M. Hocking, Roslin Institute
  • David Morrice, Roslin Institute
  • Dirk-Jan de Koning, Roslin Institute
  • Andy Law, Roslin Institute
  • Neil Bartly, Roslin Institute
  • David W. Burt, Roslin Institute
  • Henry Hunt, United States Department of Agriculture
  • Hans H. Cheng, United States Department of Agriculture
  • Ulrika Gunnarsson, Uppsala University
  • Per Wahlberg, Uppsala University
  • Leif Andersson, Uppsala University
  • Ellen Kindlund, Karolinska Institutet
  • Martti T. Tammi, Karolinska Institutet
  • Björn Andersson, Karolinska Institutet
  • Caleb Webber, University of Oxford
  • Chris P. Ponting, University of Oxford
  • Ian M. Overton, University of Manchester Institute of Science and Technology
  • Paul E. Boardman, University of Manchester Institute of Science and Technology
  • Haizhou Tang, University of Manchester Institute of Science and Technology
  • Simon J. Hubbard, University of Manchester Institute of Science and Technology
  • Stuart A. Wilson, University of Sheffield
  • Jun Yu, Beijing Institute of Genomics of Chinese Academy of Sciences
  • Jian Wang, Beijing Institute of Genomics of Chinese Academy of Sciences
  • HuanMing Yang, Beijing Institute of Genomics of Chinese Academy of Sciences
Document Type
Article
Publication Version
Published Version
Publication Date
12-1-2004
DOI
10.1038/nature03156
Abstract

We describe a genetic variation map for the chicken genome containing 2.8 million single-nucleotide polymorphisms (SNPs). This map is based on a comparison of the sequences of three domestic chicken breeds (a broiler, a layer and a Chinese silkie) with that of their wild ancestor, red jungle fowl. Subsequent experiments indicate that at least 90% of the variant sites are true SNPs, and at least 70% are common SNPs that segregate in many domestic breeds. Mean nucleotide diversity is about five SNPs per kilobase for almost every possible comparison between red jungle fowl and domestic lines, between two different domestic lines, and within domestic lines—in contrast to the notion that domestic animals are highly inbred relative to their wild ancestors. In fact, most of the SNPs originated before domestication, and there is little evidence of selective sweeps for adaptive alleles on length scales greater than 100 kilobases.

Comments

This article is from Nature 432 (2004): 717, doi:10.1038/nature03156.

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Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.
Language
en
File Format
application/pdf
Citation Information
Gane Ka-Shu Wong, Bin Liu, Jun Wang, Yong Zhang, et al.. "A Genetic Variation Map for Chicken with 2.8 Million Single-Nucleotide Polymorphisms" Nature Vol. 432 Iss. (2004) p. 717 - 722
Available at: http://works.bepress.com/susan_lamont/67/