Skip to main content
Article
Immune-Related Gene Expression in Two B-Complex Disparate Genetically Inbred Fayoumi Chicken Lines Following Eimeria maxima Infection
Poultry Science
  • D, K, Kim, United States Department of Agriculture
  • Hyun S. Lillehoj, United States Department of Agriculture
  • Y. H. Hong, United States Department of Agriculture
  • D. W. Park, United States Department of Agriculture
  • Susan J. Lamont, Iowa State University
  • J. Y. Han, Seoul National University
  • Eivind B. Lillehoj, University of Maryland School of Medicine
Document Type
Article
Publication Version
Published Version
Publication Date
1-1-2008
DOI
10.3382/ps.2007-00383
Abstract

To investigate the influence of genetic differences in the MHC on susceptibility to avian coccidiosis, M5.1 and M15.2 B-haplotype-disparate Fayoumi chickens were orally infected with live Eimeria maxima oocysts, and BW gain, fecal oocyst production, and expression of 14 immune-related genes were determined as parameters of protective immunity. Weight loss was reduced and fecal parasite numbers were lower in birds of the M5.1 line compared with M15.2 line birds. Intestinal intraepithelial lymphocytes from M5.1 chickens expressed greater levels of transcripts encoding interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, IL-8, IL-12, IL-15, IL-17A, inducible nitric oxide synthase, and lipopolysaccharide-induced tumor necrosis factor-α factor and lower levels of mRNA for IFN-α, IL-10, IL-17D, NK-lysin, and tumor necrosis factor superfamily 15 compared with the M15.2 line. In the spleen, E. maxima infection was associated with greater expression levels of IFN-γ, IL-15, and IL-8 and lower levels of IL-6, IL-17D, and IL-12 in M5.1 vs. M15.2 birds. These results suggest that genetic determinants within the chicken MHC influence resistance to E. maxima infection by controlling the local and systemic expression of immune-related cytokine and chemokine genes.

Comments

This article is from Poultry Science 87 (2008): 433, doi:10.3382/ps.2007-00383.

Rights
Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.
Language
en
File Format
application/pdf
Citation Information
D, K, Kim, Hyun S. Lillehoj, Y. H. Hong, D. W. Park, et al.. "Immune-Related Gene Expression in Two B-Complex Disparate Genetically Inbred Fayoumi Chicken Lines Following Eimeria maxima Infection" Poultry Science Vol. 87 Iss. 3 (2008) p. 433 - 443
Available at: http://works.bepress.com/susan_lamont/65/