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Article
Genetically Disparate Fayoumi Chicken Lines Show Different Response to Avian Necrotic Enteritis
The Journal of Poultry Science
  • Duk K. Kim, United States Department of Agriculture
  • Hyun S. Lillehoj, United States Department of Agriculture
  • Seung I. Jang, United States Department of Agriculture
  • Sung H. Lee, United States Department of Agriculture
  • Yeong H. Hong, Chung-Ang University
  • Susan J. Lamont, Iowa State University
Document Type
Article
Publication Version
Published Version
Publication Date
5-1-2015
DOI
10.2141/jpsa.0140203
Abstract
Necrotic enteritis (NE) has reemerged as a significant problem as a result of growing restrictions of antibiotics in agricultural animal production and increasing concerns over antibiotic resistance in human pathogens. To enhance our understanding of host-pathogen immunobiology in NE, transcriptional analysis was conducted to compare changes in NE-induced intestinal transcripts and to identify immune-related genes whose expression are associated with NE disease resistance using two genetically disparate Fayoumi chicken lines, M5.1 and M15.2. NE was induced by co-infection of Eimeria maxima and Clostridium perfringens using an established disease model and two major NE-induced clinical signs, body weight loss and intestinal lesions, were measured in two inbred Fayoumi chicken lines, M5.1 and M15.2. In the clinical criteria, line M5.1 chickens were more resistant to NE compared to line 15.2 birds. Although they have the same genetic background, these two chicken lines are genetically disparate at their major histocompatibility complex (MHC) and this difference was reflected in the differential expression patterns of several inflammatory genes such as suppressor of cytokine signaling 3 (SOCS3), interleukin 8 (IL8), nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta (NFKBIZ), serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 (SERPINF1), and gap junction protein, alpha 1, 43kDa (GJA1) between NE-afflicted and uninfected chickens. These results will lead to increased insights on the NE disease resistance mechanisms and the role of host genes controlling host immune response to C. perfringens.
Comments

This article is from The Journal of Poultry Science 52 (2015): 245, doi:10.2141/jpsa.0140203.

Rights
Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.
Language
en
File Format
application/pdf
Citation Information
Duk K. Kim, Hyun S. Lillehoj, Seung I. Jang, Sung H. Lee, et al.. "Genetically Disparate Fayoumi Chicken Lines Show Different Response to Avian Necrotic Enteritis" The Journal of Poultry Science Vol. 52 Iss. 4 (2015) p. 245 - 252
Available at: http://works.bepress.com/susan_lamont/49/