Host-Pathogen Protein-Protein Interaction Prediction Using an in silico ModelAnimal Industry Report
Extension NumberASL R3094
Summary and ImplicationsNewcastle Disease (ND) is caused by Newcastle Disease Virus (NDV) and is a major problem in developing countries where vaccination against NDV is not easily achievable. A step required for NDV infection is the cleavage of the NDV fusion (F) protein. Using structural information of the NDV F protein and the only known host protein binding partner, protein disulfide isomerase A3 (PDIA3), we computer modeled the interaction between the two proteins by looking at a docked structure of these two proteins. With our docked structure, we visualized one of the catalytic domains of PDIA3 being near the cleavage site of the NDV F protein. We also discovered a novel binding pocket on the NDV F protein that interacts with the second catalytic domain of PDIA3. This new insight may provide additional molecular targets for NDV vaccine development.
Copyright HolderIowa State University
Citation InformationJohn C. F. Hsieh, Robert L. Jernigan and Susan J. Lamont. "Host-Pathogen Protein-Protein Interaction Prediction Using an in silico Model" (2016)
Available at: http://works.bepress.com/susan_lamont/107/