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Mechanisms of Mouse Hepatitis Virus Entry into Cells
Research Day
Location
Philadelphia Campus
Start Date
2-5-2012 2:00 PM
End Date
2-5-2012 4:00 PM
Disciplines
Description
Background: Viruses can enter cells through several mechanisms, two common ones being clathrin-mediated and caveolin-mediated endocytosis. The clathrin pathway delivers viral particles to endosomes, with subsequent acidification of the endosome and endosome/lysosome fusion often a prerequisite for release of the viral genome into the cytoplasm. The caveolin-mediated pathway delivers virus initially into vesicles called caveosomes, which have a neutral pH, before viral uncoating occurs. Viral entry pathways can be examined by using various drugs to inhibit the different endocytosis pathways, as well as by siRNA technology to down-regulate expression of clathrin or caveolin proteins on the surface of host cells.
Citation Information
Philip J. Koehler, Kristina Cade, Fiora D Zoga and Susan T. Hingley. "Mechanisms of Mouse Hepatitis Virus Entry into Cells" (2012) Available at: http://works.bepress.com/susan_hingley/9/