The upstream industry uses diverse risk mitigation approaches to mitigate eventual failures within its facilities. Yet, these approaches could not avert major accidents, on different scales, from happening as they negatively affect the industry. The purpose of this paper is to assess Generated Risk Event Effect Neutralization (GREEN) as a new tool to select suitable risk mitigation approach to prevent prospective failures in upstream industry. More than 200 hundred major accidents in the industry underwent GREEN evaluation and compared with existing risk mitigation approaches used in to mitigate eventual failures. Kuwait's’ Mina Al-Ahmadi explosion was chosen as a case study to apply GREEN. The results of GREEN analyses were compared to both petroleum industry's standards and best practices, as well as the evaluation from the design team at Kuwait's Mina Al-Ahmadi to validate the result.