The Programme for International Student Assessment (PISA) is an assessment that measures the knowledge and skills of 15-year-old students, an age at which they have nearly completed compulsory schooling. PISA assesses young adults’ ability to apply their knowledge and skills to real-life problems and situations rather than how well they have learned a specific curriculum. This PISA in Brief report provides a summary of student performance in the PISA 2022 assessment and tells us about their capacity to apply knowledge and skills in the domains of reading, mathematical, and scientific literacy.