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Article
Expanded CAG/CTG repeats in bipolar disorder: no correlation with phenotypic measures of illness severity
Biological psychiatry
  • N. Craddock
  • P. McKeon
  • Sue Moorhead, University of Iowa
  • C. Guy
  • D. Harrison
  • L. Mynett-Johnson
  • E. Claffey
  • E. Feldman
  • P. McGuffin
  • M. J. Owen
  • M. C. O'Donovan
Document Type
Article
Peer Reviewed
1
Publication Date
11-15-1997
NLM Title Abbreviation
Biol Psychiatry
PubMed ID
9359972
DOI of Published Version
10.1016/S0006-3223(96)00516-1
Abstract

The hypothesis that expanded trinucleotide repeats (TNRs) contribute to the pathogenesis of bipolar disorder has received strong support from recent studies showing that, on average, bipolar patients carry larger repeat sequences of the TNR motif CAG/CTG than do controls. It has been postulated that intergenerational expansion of a TNR may be responsible for the tendency for age of onset to become earlier in younger generations (anticipation) observed in some bipolar pedigrees, and that length polymorphism may account for variability in clinical phenotype. We have used the method of repeat expansion detection to examine these predictions in a sample of 133 Caucasian DSM-III-R bipolar I probands from the British Isles. We found no evidence to support the notion that CAG/CTG TNR genes are major determinants of phenotypic severity or age at onset in the population examined, and conclude that for most cases of bipolar disorder TNR genes may operate as susceptibility genes rather than as single genes of major effect.

Keywords
  • Adult,
  • Bipolar Disorder/diagnosis/genetics/psychology,
  • Female,
  • Humans,
  • Male,
  • Middle Aged,
  • Phenotype,
  • Severity of Illness Index,
  • Trinucleotide Repeats/genetics
Published Article/Book Citation
Biological psychiatry, 42:10 (1997) pp.876-881. DOI:10.1016/S0006-3223(96)00516-1.
Disciplines
Citation Information
N. Craddock, P. McKeon, Sue Moorhead, C. Guy, et al.. "Expanded CAG/CTG repeats in bipolar disorder: no correlation with phenotypic measures of illness severity" Biological psychiatry Vol. 42 Iss. 10 (1997) p. 876 - 881 ISSN: 0006-3223
Available at: http://works.bepress.com/sue_moorhead/24/