Article
Synthesis and evaluation of functionalized aminobenzoboroxoles as potential anti-cancer agents
Journal of Organometallic Chemistry
(2015)
Abstract
Several aminobenzoboroxole derivatives have been prepared starting from o-boronobenzaldehyde employing reductive amination protocol. The corresponding aminobenzoboroxole derivatives have been further functionalized as N-nitrosoaminobenzoboroxoles as well as N-benzoboroxolylureas. These derivatives have been evaluated for their anti-cancer activity on human pancreatic cancer MIAPaCa-2 and human breast cancer MDA-MB-231 cell lines.
Keywords
- Benzoboroxoles,
- Aminobenzoboroxoles,
- Anti-Cancer agents,
- Reductive amination,
- N-Nitrosoaminobenzoboroxoles,
- N-Benzoboroxolylureas
Disciplines
Publication Date
December, 2015
DOI
10.1016/j.jorganchem.2015.06.021
Citation Information
Pathi Suman, Bhawankumar P. Patel, Agasthya V. Kasibotla, Lucas N. Solano, et al.. "Synthesis and evaluation of functionalized aminobenzoboroxoles as potential anti-cancer agents" Journal of Organometallic Chemistry Vol. 798 (2015) p. 125 - 131 ISSN: 0022-328X Available at: http://works.bepress.com/subash-jonnalagadda/3/