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Selected Works of Subash Jonnalagadda
Article
Bruton's Tyrosine Kinase Targeting in Multiple Myeloma
International Journal of Molecular Sciences (2021)
  • Max Von Suskil, Rowan University
  • Kazi Nasrin Sultana, Manipal University Jaipur
  • Weam Othman Elbezanti, Rowan University
  • Weam Othman Elbezanti, University of Texas MD Anderson Cancer Center
  • Omar S. Al-Odat, Rowan University
  • Robert Chitren, Rowan University
  • Amit K. Tiwari, University of Toledo
  • Kishore B. Challagundla, University of Nebraska Medical Center
  • Sandeep Kumar Srivastava, Manipal University Jaipur
  • Subash C. Jonnalagadda, Rowan University
  • Tulin Budak-Alpdogan, University of Texas MD Anderson Cancer Center
  • Manoj K. Pandey, Rowan University
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Abstract
Multiple myeloma (MM), a clonal plasma cell disorder, disrupts the bones’ hematopoiesis and microenvironment homeostasis and ability to mediate an immune response against malignant clones. Despite prominent survival improvement with newer treatment modalities since the 2000s, MM is still considered a non-curable disease. Patients experience disease recurrence episodes with clonal evolution, and with each relapse disease comes back with a more aggressive phenotype. Bruton’s Tyrosine Kinase (BTK) has been a major target for B cell clonal disorders and its role in clonal plasma cell disorders is under active investigation. BTK is a cytosolic kinase which plays a major role in the immune system and its related malignancies. The BTK pathway has been shown to provide survival for malignant clone and multiple myeloma stem cells (MMSCs). BTK also regulates the malignant clones’ interaction with the bone marrow microenvironment. Hence, BTK inhibition is a promising therapeutic strategy for MM patients. In this review, the role of BTK and its signal transduction pathways are outlined in the context of MM.
Disciplines
Publication Date
May 27, 2021
DOI
10.3390/IJMS22115707
Citation Information
Max Von Suskil, Kazi Nasrin Sultana, Weam Othman Elbezanti, Weam Othman Elbezanti, et al.. "Bruton's Tyrosine Kinase Targeting in Multiple Myeloma" International Journal of Molecular Sciences Vol. 22 Iss. 11 (2021) p. 5707
Available at: http://works.bepress.com/subash-jonnalagadda/16/
Creative Commons license
Creative Commons License
This work is licensed under a Creative Commons CC_BY International License.