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Article
Low Dose Brain Radiation Reduces Elevated Plasma Branch Chain Amino Acid Levels in APP/PS1 Mice
Innovation in Aging
(2020)
Abstract
Branch Chain Amino Acids (BCAA) have recently been implicated in Alzheimer’s Disease (AD). We previously showed that low dose brain radiation (RT) [5 fractions of 2 Gy] reduces amyloid-beta plaque burden and results in improved cognition in the APP/PS1 model of AD. In this study we investigated whether this schedule of radiation altered the metabolomic profile of serum. 10 month old male (M) and female (F) APP/PS1 mice were either treated with whole brain radiotherapy (5 x 2 Gy) or received sham irradiation.
Disciplines
Publication Date
December 16, 2020
DOI
10.1093/GERONI/IGAA057.397
Citation Information
Michael Maddens, George Wilson, Stewart Graham and Ali Yilmaz. "Low Dose Brain Radiation Reduces Elevated Plasma Branch Chain Amino Acid Levels in APP/PS1 Mice" Innovation in Aging Vol. 4 (2020) p. 121 - 121 Available at: http://works.bepress.com/stewart-graham/175/