A debate at ICIS 2000 asked whether the trend toward e-business calls for changes in the fundamental concepts of information systems. This article summarizes viewpoints presented in the debate. It also presents audience feedback in the form of a vote about whether new concepts are needed and selected comments submitted by the audience about key issues in the debate. Among others, these issues include questions about what are the fundamental concepts of IS, different views of about the meaning and implications of e-business, and questions about the nature of the user in e-business.