Article
Shared and Distinct Mechanisms of Skeletal muscle atrophy: A narrative review
Ageing Research Reviews
(2021)
Abstract
Maintenance of skeletal muscle mass and function is an incredibly nuanced balance of anabolism and catabolism that can become distorted within different pathological conditions. In this paper we intend to discuss the distinct intracellular signaling events that regulate muscle protein atrophy for a given clinical occurrence. Aside from the common outcome of muscle deterioration, several conditions have at least one or more distinct mechanisms that creates unique intracellular environments that facilitate muscle loss. The subtle individuality to each of these given pathologies can provide both researchers and clinicians with specific targets of interest to further identify and increase the efficacy of medical treatments and interventions.
Disciplines
Publication Date
November, 2021
DOI
10.1016/j.arr.2021.101463
Citation Information
Dylan Wilburn, Ahmed Ismaeel, Steven Machek, Emma Fletcher, et al.. "Shared and Distinct Mechanisms of Skeletal muscle atrophy: A narrative review" Ageing Research Reviews Vol. 71 (2021) Available at: http://works.bepress.com/steven-machek/8/