Dissertation
MUTACIN 1140 AND OCCIDIOFUNGIN: NATURAL PRODUCTS ISOLATED FROM BACTERIAL SOURCES AND THEIR POTENTIAL APPLICATIONS AS THERAPEUTICS
(2017)
Abstract
Streptococcus mutans JH1140 is a bacteria which produces a lantibiotic product, named mutacin 1140. Mutacin 1140 has been shown to be effective at inhibiting Gram-positive bacterial infections caused by Staphylococcus aureus and Streptococcus pneumoniae. Mutacin 1140 is a ribosomally synthesized peptide antibiotic that undergoes extensive posttranslational modifications (PTM). We have found that Mutacin 1140 and an aminoglycoside, Kanamycin, when combined together, act synergistically against Staphylococcus aureus. All three methods are independently consistent with their results: in combination with Kanamycin, Mutacin 1140 kills at an improved rate than either compound individually. Synergistic behavior opens many interesting opportunities for altered treatment strategies.
Keywords
- Mutacin 1140,
- Natural Products,
- Bacteria,
- Occidiofungin
Disciplines
Publication Date
Fall August 21, 2017
Degree
PhD
Field of study
BIology
Department
Biological Sciences
Advisors
Dr. James Smith
Citation Information
Steven LaiHing. "MUTACIN 1140 AND OCCIDIOFUNGIN: NATURAL PRODUCTS ISOLATED FROM BACTERIAL SOURCES AND THEIR POTENTIAL APPLICATIONS AS THERAPEUTICS" (2017) Available at: http://works.bepress.com/steven-laihing/5/