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Faculty Selected Works of Steven Bruce
Article
Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium
Molecular Psychiatry (2021)
  • Emily L. Dennis
  • Seth G. Disner, University of Minnesota
  • Negar Fani, Emory University
  • Lauren E. Salminen, University of Missouri–St. Louis
  • Mark W. Logue
  • Emily K. Clarke, Duke University
  • Courtney C. Haswell, Duke University
  • Christopher L. Averill, Yale University
  • Lee A. Baugh
  • Jessica Bomyea, University of California, San Diego
  • Steven Bruce, University of Missouri-St. Louis
  • Jiook Cha, Columbia University Medical Center
  • Kyle Choi, University of California, San Diego
  • Nicholas D. Davenport, University of Minnesota
  • Maria Densmore, Lawson Health Research Institute
  • Stefan du Plessis, Stellenbosch University
  • Gina L. Forster, University of Otago
  • Jessie L. Frijling, University of Amsterdam
  • Atilla Gonenc, McLean Hospital
  • Staci Gruber, Harvard University
  • Daniel W. Grupe, University of Wisconsin-Madison
  • Jeffrey P. Guenette, Brigham and Women's Hospital
  • Jasmeet P. Hayes
  • David Hofmann, University of Münster
  • Jonathan Ipser, University of Cape Town
  • Tanja Jovanovic, Emory University
  • sinead kelly
  • Mitzy Kennis, United Kingdom Ministry of Defence
  • Philipp Kinzel, Ludwig Maximilian University of Munich
  • Saskia B. J. Koch, Radboud University Nijmegen
  • Inga Koerte, Brigham and Women's Hospital
  • Sheri Koopowitz, University of Cape Town
  • Mayuresh Korgaonkar, University of Sydney
  • John Krystal, Yale University
  • Lauren A. M. Lebois, Harvard University
  • Gen Li
  • Vincent A. Magnotta
  • Antje Manthey, Charité
  • Geoff J. May
  • Deleene S. Menefee
  • Laura Nawijn, University of Amsterdam
  • Steven M. Nelson
  • Richard W.J. Neufeld
  • Jack B. Nitschke
  • Daniel O’Doherty
  • Matthew Peverill
  • Kerry J. Ressler, Emory University
  • Annerine Roos
  • Margaret A. Sheridan, University of North Carolina at Chapel Hill
  • Anika Sierk
  • Alan H. Simmons
  • Raluca M. Simons
  • Jeffrey S. Simons
  • Jennifer Stevens, Eastern Illinois University
  • Benjamin Suarez-Jimenez
  • Danielle R. Sullivan
  • Jean Théberge
  • Jana K. Tran
  • Leigh van den Heuvel
  • Steven J. A. van der Werff
  • Sanne J. H. van Rooij
  • Mirjam van Zuiden
  • Carmen Velez, University of Missouri–St. Louis
  • Mieke Verfaellie
  • Robert R. J. M. Vermeiren
  • Benjamin S. C. Wade, University of Missouri–St. Louis
  • Tor D. Wager
  • Henrik Walter
  • Sherry Winternitz
  • Jonathan Wolff, University of Oxford
  • Gerald York
  • Ye Zhu
  • Xi Zhu
  • Chadi G. Abdallah
  • Richard Bryant
  • Judith K. Daniels
  • Richard J. Davidson, University of Wisconsin-Madison
  • Kelene A Fercho
  • Carol Franz
  • Elbert Geuze
  • Evan M. Gordon
  • Milissa L. Kaufman
  • William S. Kremen
  • Jim Lagopoulos
  • Ruth A Lanius
  • Michael J. Lyons
  • Stephen R. McCauley, Baylor College of Medicine
  • Regina McGlinchey
  • Katie A. McLaughlin
  • William Milberg
  • Yuval Neria
  • Miranda Olff
  • Soraya Seedat, Stellenbosch University
  • Martha Shenton, Brigham and Women's Hospital
  • Scott R. Sponheim, University of Minnesota
  • Dan J. Stein
  • Murray B. Stein, University of California, San Diego
  • Thomas Straube
  • David F. Tate
  • Nic J. A. van der Wee
  • Dick J. Veltman, VU University Amsterdam
  • Li. Wang
  • Elisabeth A. Wilde
  • Paul M. Thompson
  • Peter Kochunov, University of Maryland, Baltimore
  • Neda Jahanshad
  • Rajendra A. Morey, Duke University
Link
Abstract
A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have been mixed which may be partially due to relatively small sample sizes among studies. Altered structural connectivity may be both a neurobiological vulnerability for, and a result of, PTSD. In an effort to find reliable effects, we present a multi-cohort analysis of dMRI metrics across 3047 individuals from 28 cohorts currently participating in the PGC-ENIGMA PTSD working group (a joint partnership between the Psychiatric Genomics Consortium and the Enhancing NeuroImaging Genetics through Meta-Analysis consortium). Comparing regional white matter metrics across the full brain in 1426 individuals with PTSD and 1621 controls (2174 males/873 females) between ages 18–83, 92% of whom were trauma-exposed, we report associations between PTSD and disrupted white matter organization measured by lower fractional anisotropy (FA) in the tapetum region of the corpus callosum (Cohen’s d = −0.11, p = 0.0055). The tapetum connects the left and right hippocampus, for which structure and function have been consistently implicated in PTSD. Results were consistent even after accounting for the effects of multiple potentially confounding variables: childhood trauma exposure, comorbid depression, history of traumatic brain injury, current alcohol abuse or dependence, and current use of psychotropic medications. Our results show that PTSD may be associated with alterations in the broader hippocampal network.
Disciplines
Publication Date
2021
DOI
10.1038/S41380-019-0631-X
Citation Information
Emily L. Dennis, Seth G. Disner, Negar Fani, Lauren E. Salminen, et al.. "Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium" Molecular Psychiatry Vol. 26 (2021)
Available at: http://works.bepress.com/steven-bruce/89/