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About Steven J Schrodi

In the past my research focused on the physical sciences, molecular evolutionary genetics and methods of analyzing gene expression data. My undergraduate work was done at UC Davis and I hold a Ph.D. from UC Irvine. Much of my dissertation involved investigating the patterns of coding region substitution variability (ways of measuring the variability, empirical studies of the variability in mammals and hypothesis testing) in an attempt to better understand the nature of population genetic models that might give rise to such patterns. Interestingly, the dispersion index was found to significantly increase over time for mammals. (This work was done in collaboration with John Gillespie, Dick Hudson and Walter Fitch.) I also developed and analyzed stochastic models of haploid evolution and led a substantial effort to develop computational methods to address the analysis of shared chromosomal regions in extremely large and complex extended families with segregating disease variants (collaborators: Ray White, Nori Matsunami, Veronica Garcia and Hywel Jones).
I'm currently a tenure-track research scientist at the Marshfield Clinic Research Foundation at the Center for Human Genetics. My lab focuses on both experimental work mapping disease genes as well as genetics theory and applied probability. Understanding the genetics underlying variation in Th17-mediated activity and the causes of aberrant, pathogenic IL-23/IL-17 signaling is a central aim of my empirical research. With regard to theory, my lab is currently investigating sequencing analysis methods, large-scale simulation of disease models in distantly-related individuals, and the decay of linkage disequilibrium from disease-causing variants.
Prior to my position at Marshfield, I was a senior staff scientist at Celera, located in Alameda, CA. My primary interests there centered around applying mathematical and statistical methods to investigate interesting questions in genetics, better understand genetic processes, and construct genetics theory. Among the projects I have recently worked on include disease-gene mapping, whole-genome association mapping methods, fine mapping approaches, genetic prognostic theory, Bayesian methodology and application of population genetics to disease mapping. Further, I attempt to keep active in genetics theory, empirical experiments (particularly those related to disease traits), and statistical methods, primarily probability-based, connecting the two for it is my view that a robust interplay between these three aspects of science is the engine behind robust scientific progress.
I am also involved in many empirical studies of common-disease genetics, largely revolving around genome-wide association approaches and extended family linkage studies. The majority of my work in this area has concentrated on mapping autoimmune and autoinflammatory diseases. With the collaboration of my colleagues, these efforts have resulted in several findings including the R620W missense SNP in the protein tyrosine phosphatase PTPN22 and 9q33.2-linked variants residing in the TNF receptor factor adaptor-encoding TRAF1 gene being correlated with rheumatoid arthritis; and several polymorphisms within cytokine-related genes – two missense SNPs (L310P and Q381R) in IL23R, haplotypes in IL12B, and SNPs in IL13 – being in linkage disequilibrium with psoriasis vulgaris (collaborators: Joe Catanese, Victoria Carlton, Ann Begovich, Peter Gregersen, Mike Seldin, Lindsey Criswell, Ellen Beasley, Linda McAllister, Michele Cargill, Monica Chang, Veronica Garcia, Jerry Krueger, Kristina Callis Duffin, Nori Matsunami, Mark Leppert, Lineagen, John Sninsky). All of these disease-association findings have been independently replicated by other investigators. In addition, I have worked on association studies for neurodegenerative diseases, hepatic fibrosis progression, and fatty liver diseases (collaborators: Andrew Grupe, Yonghong Li, Anand Chokkalingam, John Sninsky). Recently I've looked into copy-number variation (collaborators: Andrew Grupe, Charley Rowland).
Aside from those topics listed above, I am also interested in other fields including:
(1) The fundamentals of probability theory and statistical inference
(2) Anthropological genetics
(3) The mathematics of self-reproducing systems
(4) Analytic philosophy, foundations of science and the philosophy of language
Steve Schrodi
Associate Research Scientist
Center for Human Genetics
Marshfield Clinic Research Foundation
Principal Investigator
University of Wisconsin-Institute for Clinical and Translational Research


Present Computation and Informatics in Biology and Medicine, Marshfield Clinic Research Foundation / University of Wisconsin-Madison
Present Principal Investigator / Faculty, Marshfield Clinic Research Foundation / University of Wisconsin-Madison

Curriculum Vitae

Research Interests

Human Genetics, Statistical Genetics, Genetics Theory, Mathematical methods applied to Biology

Contact Information

Steven J Schrodi
Center for Human Genetics
Marshfield Clinic Research Foundation
1000 North Oak Avenue - MLR
Marshfield, WI 54449
Phone: (715) 221-6443

Disease Gene Mapping, Psoriasis, IL12/23 (4)

Diabetes Prediction (1)

Disease Gene Mapping, Psoriasis, IL13 (3)

Disease Gene Mapping, Psoriasis, Other loci (5)

Disease Gene Mapping, Neurodegeneration, Parkinsons (3)

Disease Gene Mapping, Neurodegeneration, Alzheimers (4)

Disease Gene Mapping, Rheumatoid Arthritis PTPN22 (2)

Disease Gene Mapping, Rheumatoid Arthritis 9q33 (3)