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Intramolecular S···O Chalcogen Bond as Stabilizing Factor in Geometry of Substituted Phenyl-SF3 Molecules
Journal of Organic Chemistry
  • Vincent de Paul Nziko, Utah State University
  • Steve Scheiner, utah state university
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American Chemical Society
Density functional methods are used to examine the geometries and energetics of molecules containing a phenyl ring joined to the trigonal bipyramidal SF3 framework. The phenyl ring has a strong preference for an equatorial position. This preference remains when one or two ether -CH2OCH3 groups are added to the phenyl ring, ortho to SF3, wherein an apical structure lies nearly 30 kcal/mol higher in energy. Whether equatorial or apical, the molecule is stabilized by a S···O chalcogen bond, sometimes augmented by CH···F or CH···O H-bonds. The strength of the intramolecular S···O bond is estimated to lie in the range between 3 and 6 kcal/mol. A secondary effect of the S···O chalcogen bond is elongation of the S-F bonds. Solvation of the molecule strengthens the S···O interaction. Addition of substituents to the phenyl ring has only modest effects upon the S···O bond strength. A strengthening arises when an electron-withdrawing substituent is placed ortho to the ether and meta to SF3, while electron-releasing species produce an opposite effect.
Citation Information
Vincent de Paul Nziko and Steve Scheiner. "Intramolecular S···O Chalcogen Bond as Stabilizing Factor in Geometry of Substituted Phenyl-SF3 Molecules" Journal of Organic Chemistry Vol. 80 Iss. 4 (2015) p. 2356 - 2363
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