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Ingredients Necessary for Proton Transfer in Enzymes
Israel Journal of Chemistry (2009)
  • Steve Scheiner, Utah State University

The transfer of a proton across a hydrogen bond can be influenced by a number of factors, including H-bond length, intramolecular angles, and the presence of neighboring groups. The ability of different factors to push a proton across the H-bond is examined for a specific and very important pair of catalytic groups, Ser-195 and His-57, within the context of a serine proteinase enzyme. The influence of residue Asp-102 is considered for different charge states, as is the nature of the surrounding medium. Also examined are the perturbations introduced by the substrate and external ions and dipoles.

  • ingredients,
  • necessary,
  • proton,
  • transfer,
  • enzymes
Publication Date
January 1, 2009
Citation Information
Ingredients Necessary for Proton Transfer in Enzymes S. Scheiner Isr. J. Chem. 2009 49 139-147