Important to the development of dye-sensitized solar cells is the longevity and photo-conversion efficiency of the dye. To improve cost effectiveness, dyes of superior thermal and chemical stability are desirable to extend device performance. In this study, we examine a series of peripherally fluorinated Zinc-Phthalocyanines (FxZnPc). Introduction of chemically inert fluorine and isopropyl fluoroalkyl groups on the periphery of the Pc improve the dye stability and allow for tunable photo-physical properties. Additionally, introduction of the bulky isopropyl fluoroalkyl groups help mitigate molecular aggregation in thin films which is known to be detrimental to maintaining the desired photo-physical properties of the surface coating. Using molecular dynamics and first principles modeling, various substituent effects on surface adhesion and aggregation over TiO2 surfaces are characterized for both symmetric and asymmetric substitution.