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Selected Works of Stephen O'Brien
Article
Immunologic Profile of Highly Exposed Yet HIV Type 1-Seronegative Men
AIDS Research and Human Retroviruses
  • Otto Yang, University of California - Los Angeles
  • W. John Boscardin, University of California - Los Angeles
  • Jose Matud, University of California - Los Angeles
  • Mary Ann Hausner, University of California - Los Angeles
  • Lance E. Hultin, University of California - Los Angeles
  • Patricia M. Hultin, University of California - Los Angeles
  • Roger Shih, University of California - Los Angeles
  • John Ferbas, University of California - Los Angeles
  • Frederick P. Siegal, Saint Vincent Catholic Medical Center
  • Michael Shodell, Saint Vincent Catholic Medical Center
  • Gene M. Shearer, National Cancer Institute at Bethesda
  • Edith Grene, National Cancer Institute at Bethesda
  • Mary Carrington, National Cancer Institute at Frederick
  • Stephen J. O'Brien, National Cancer Institute at Frederick
  • Charles B. Price, University of California - Los Angeles
  • Roger Detels, University of California - Los Angeles
  • Beth D. Jamieson, University of California - Los Angeles
  • Janis Giorgi, University of California at Los Angeles
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Document Type
Article
Publication Date
9-1-2002
Disciplines
Abstract

The host immune factors that determine susceptibility to HIV-1 infection are poorly understood. We compared multiple immunologic parameters in three groups of HIV-1-seronegative men: 14 highly exposed (HR10), 7 previously reported possibly to have sustained transient infection (PTI), and a control group of 14 low risk blood bank donors (BB). Virus-specific cellular immune assays were performed for CD4+ T helper cell responses, CD8+cytotoxic T lymphocyte activity, CD8+ cell chemokine release, and CD8+ cell-derived antiviral soluble factor activity. General immune parameters evaluated included CCR5 genotype and phenotype, interferon α production by PBMCs, leukocyte subset analysis, and detailed T lymphocyte phenotyping. Comparisons revealed no detectable group-specific differences in measures of virus-specific immunity. However, the HR10 group differed from the BB group in several general immune parameters, having higher absolute monocyte counts, higher absolute CD8+ T cell counts and percentages, lower naive and higher terminal effector CD8+ cells, and lower levels of CD28+CD8+cells. These changes were not associated with seropositivity for other chronic viral infections. The PTI men appeared to have normal levels of monocytes and slightly elevated levels of CD8+ T cells (also with increased effector and decreased naive cells). Although we cannot entirely exclude the contribution of other chronic viral infections, these findings suggest that long-lived systemic cellular antiviral immunity as detected by our assays is not a common mechanism for resistance to infection, and that resistance may be multifactorial. General immune parameters reflected by CD8+ T cell levels and activation, and monocyte concentrations may affect the risk of infection with HIV-1, and/or serve as markers of exposure.

Comments

©2002 Mary Ann Liebert, Inc.

ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
Citation Information
Otto Yang, W. John Boscardin, Jose Matud, Mary Ann Hausner, et al.. "Immunologic Profile of Highly Exposed Yet HIV Type 1-Seronegative Men" AIDS Research and Human Retroviruses Vol. 18 Iss. 14 (2002) p. 1051 - 1065 ISSN: 0889-2229
Available at: http://works.bepress.com/stephen-obrien/368/