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Article
Cloning, Characterization, Expression, and Chromosomal Localization of a Human Ferritin Heavy-Chain Gene
Proceedings of the National Academy of Sciences of the United States of America
  • Matthias W. Hentze, National Institute of Child Health and Human Development
  • Stephen Keim, National Institute of Child Health and Human Development
  • Panos Papadopoulos, Tufts University School of Medicine
  • Stephen J. O'Brien, National Cancer Institute at Frederick
  • William Modi, National Cancer Institute at Frederick
  • Jim Drysdale, Tufts University School of Medicine
  • William J. Leonard, National Institute of Child Health and Human Development
  • Joe B. Harford, National Institute of Child Health and Human Development
  • Richard D. Klausner, National Institute of Child Health and Human Development
Document Type
Article
Publication Date
10-1-1986
Keywords
  • Iron-storage protein
Abstract

A genomic phage clone containing a full-length copy of a functional human gene for ferritin heavy chain has been isolated. The gene consists of four exons spanning approximately 3 kilobases and has been localized to chromosome 11. The functionality of the gene was demonstrated by the fact that both transient transfectants and stable transformants of murine fibroblasts actively transcribe human ferritin heavy-chain mRNA.

Additional Comments
National Institute of Health Grant #AM17775
ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
Citation Information
Matthias W. Hentze, Stephen Keim, Panos Papadopoulos, Stephen J. O'Brien, et al.. "Cloning, Characterization, Expression, and Chromosomal Localization of a Human Ferritin Heavy-Chain Gene" Proceedings of the National Academy of Sciences of the United States of America Vol. 83 Iss. 19 (1986) p. 7226 - 7230 ISSN: 1091-6490
Available at: http://works.bepress.com/stephen-obrien/131/