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Synchrotron photoactivation of cisplatin elicits an extra number of DNA breaks that stimulate RAD51-mediated repair pathways
Faculty of Engineering and Information Sciences - Papers
  • stéphanie corde, European Synchrotron Radiation Facility
  • Jacques Balosso, Centre Hospitalier Regional Universitaire
  • Helene Elleaume, European Synchrotron Radiation Facility
  • Michel Renier, European Synchrotron Radiation Facility
  • Aurelie Joubert, European Synchrotron Radiation Facility
  • Marie-Claude Biston, European Synchrotron Radiation Facility
  • Jean-Francois Adam, European Synchrotron Radiation Facility
  • Anne-Marie Charvet, European Synchrotron Radiation Facility
  • Thierry Brochard, European Synchrotron Radiation Facility
  • Jean-Francois Le Bas, Centre Hospitalier Regional Universitaire
  • Francois Esteve, European Synchrotron Radiation Facility
  • Nicolas Foray, European Synchrotron Radiation Facility
RIS ID
76642
Publication Date
1-1-2003
Publication Details

corde, s., Balosso, J., Elleaume, H., Renier, M., Joubert, A., Biston, M., Adam, J., Charvet, A., Brochard, T., Le Bas, J., Esteve, F. & Foray, N. (2003). Synchrotron photoactivation of cisplatin elicits an extra number of DNA breaks that stimulate RAD51-mediated repair pathways. Cancer Research, 63 3221-3227.

Abstract

Combination of cis-platinum with ionizing radiation is one of the most promising anticancer treatments that appears to be more efficient than radiotherapy alone. Unlike conventional X-ray emitters, accelerators of high energy particles like synchrotrons display powerful and monochromatizable radiation that makes the induction of an Auger electron cascade in cis-platinum molecules [also called photoactivation of cis-platinum (PAT-Plat)] theoretically possible. Here, we examined the molecular consequences of one of the first attempts of synchrotron PAT-Plat, performed at the European Synchrotron Research Facility (Grenoble-France). PATPlat was found to result in an extra number of slowly repairable DNA double-strand breaks, inhibition of DNA-protein kinase activity, dramatic nuclear relocalization of RAD51, hyperphosphorylation of the BRCA1 protein, and activation of proto-oncogenic c-Abl tyrosine kinase.

Citation Information
stéphanie corde, Jacques Balosso, Helene Elleaume, Michel Renier, et al.. "Synchrotron photoactivation of cisplatin elicits an extra number of DNA breaks that stimulate RAD51-mediated repair pathways" (2003)
Available at: http://works.bepress.com/stephanie_corde/5/