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Article
Absolute cerebral blood volume and blood flow measurements based on synchrotron radiation quantitative computed tomography
Faculty of Engineering and Information Sciences - Papers
  • Jean-Francois Adam, European Synchrotron Radiation Facility
  • Helene Elleaume, European Synchrotron Radiation Facility
  • Geraldine Le Duc, European Synchrotron Radiation Facility
  • Stéphanie Corde, European Synchrotron Radiation Facility
  • Anne-Marie Charvet, European Synchrotron Radiation Facility
  • Irene Tropres, European Synchrotron Radiation Facility
  • Jean-Francois Le Bas, European Synchrotron Radiation Facility
  • Francois Esteve, European Synchrotron Radiation Facility
RIS ID
76649
Publication Date
1-1-2003
Publication Details

Adam, J., Elleaume, H., Le Duc, G., Corde, S., Charvet, A., Tropres, I., Le Bas, J. & Esteve, F. (2003). Absolute cerebral blood volume and blood flow measurements based on synchrotron radiation quantitative computed tomography. Journal of cerebral blood flow metabolism, 23 (4), 499-512.

Abstract
Synchrotron radiation computed tomography opens new fields by using monochromatic x-ray beams. This technique allows one to measure in vivo absolute contrast-agent concentrations with high accuracy and precision, and absolute cerebral blood volume or flow can be derived from these measurements using tracer kinetic methods. The authors injected an intravenous bolus of an iodinated contrast agent in healthy rats, and acquired computed tomography images to follow the temporal evolution of the contrast material in the blood circulation. The first image acquired before iodine infusion was subtracted from the others to obtain computed tomography slices expressed in absolute iodine concentrations. Cerebral blood volume and cerebral blood flow maps were obtained after correction for partial volume effects. Mean cerebral blood volume and flow values (n 7) were 2.1 ± 0.38 mL/100 g and 129 ± 18 mL · 100 g−1 · min−1 in the parietal cortex; and 1.92 ± 0.32 mL/100 g and 125 ± 17 mL · 100 g−1 · min−1 in the caudate putamen, respectively. Synchrotron radiation computed tomography has the potential to assess these two brainperfusion parameters. Key Words: Synchrotron radiation— Computed tomography—Cerebral blood volume—Cerebral blood flow—Iodinated contrast agent—Partial volume effects.
Citation Information
Jean-Francois Adam, Helene Elleaume, Geraldine Le Duc, Stéphanie Corde, et al.. "Absolute cerebral blood volume and blood flow measurements based on synchrotron radiation quantitative computed tomography" (2003)
Available at: http://works.bepress.com/stephanie_corde/10/