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Enhanced pro-apoptotic and anti-adipogenic effects of genistein plus guggulsterone in 3T3-L1 adipocytes
BioFactors
  • Jeongyeh Yang
  • Mary Anne Della-Fera
  • Srujana Rayalam, Philadelphia College of Osteopathic Medicine
  • Suresh Ambati
  • Clifton A. Baile
Document Type
Article
Publication Date
1-1-2007
Abstract
Genistein (G), an isoflavone, and guggulsterone (GS), the active substance in guggulipid, have been reported to possess therapeutic effects for obesity. In the present study, we investigated the effects of combinations of G plus GS on apoptosis and adipogenesis in 3T3-L1 cells. In mature adipocytes, G and GS individually caused apoptosis, but combination of G plus GS significantly increased apoptosis, more than either compound alone. Furthermore, G plus GS caused a greater increase in procaspase-3 cleavage, Bax expression, cytochrome c release, and proteolytic cleavage of PARP than either compound alone. In maturing preadipocytes G and GS each suppressed lipid accumulation, but the combination potentiated the inhibition of lipid accumulation. These results suggest that combination of genistein and guggulsterone may exert anti-obesity effects by inhibiting adipogenesis and inducing apoptosis in adipocytes. © 2007 - IUBMB/IOS Press and the authors. All rights reserved.
Comments

This article was published in BioFactors, Volume 30, Issue 3, Pages 159-169.

The published version is available at http://dx.doi.org/10.1002/biof.5520300303.

Copyright © 2007 IUBMB.

Citation Information
Jeongyeh Yang, Mary Anne Della-Fera, Srujana Rayalam, Suresh Ambati, et al.. "Enhanced pro-apoptotic and anti-adipogenic effects of genistein plus guggulsterone in 3T3-L1 adipocytes" BioFactors Vol. 30 Iss. 3 (2007) p. 159 - 169
Available at: http://works.bepress.com/srujana_rayalam/12/