This report presents the research conducted as part of an investigation for the California Department of Transportation (Caltrans) regarding the seismic response and overall moment capacity of precast I-girder to inverted-T bent cap bridge connections for seismic applications. The current design practice, as outlined by Caltrans’ Seismic Design Criteria, assumes that the connection between the precast I-girders and the inverted-T bent cap will degrade in a seismic event and shall therefore be designed as a pinned connection, making the precast girder option for seismic bridges inefficient. A prototype I-girder to inverted-T bent cap bridge and a 50% scale test unit was designed in order to investigate the behavior of the as-built girder-to-cap connection region. Additionally, per the request of Caltrans, an improved girder-to-cap connection detail was developed in order to ensure a fully continuous moment connection between the I-girders and inverted-T bent cap. A finite element grillage model was developed using ABAQUS and SAP2000 and was used to predict the global and local responses of various aspects of the test unit. The test unit was constructed and tested in two phases of quasi-static cyclic testing. The first phase was a horizontal load test phase, which simulated the effects of gravity and seismic loads on the entire test unit. The second phase was a vertical load test phase, which specifically focused on the positive and negative moment capacity of the connections. Both the results of the finite element grillage model and the testing were used to make conclusions regarding the performance of Igirder to inverted-T bent cap bridges. It was concluded that the current I-girder to inverted-T bent cap bridge connection is capable of acting as a fully continuous connection for both positive and negative moments during both gravity and seismic loading, contrary to the design assumptions stated in Caltrans’ Seismic Design Criteria. The improved connection detail demonstrated the ability to ensure a fully continuous moment connection between the I-girders and inverted-T bent cap. Both connection details also exhibited a significant moment resistance beyond what was expected during the vertical load test although the as-built connection eventually failed under positive moments at moderate to large displacements.