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Contribution to Book
Metabolic Syndrome, GERD, Barrett’s Esophagus
Metabolic Syndrome: A Comprehensive Textbook (2016)
  • Sravanthi Parasa, University of Kansas Hospital
  • Arun Raghav Mahankali Sridhar, University of Kansas Hospital
Abstract
Gastroesophageal reflux disease (GERD) is on the rise with more than 20 % of the Western population reporting symptoms. GERD is the most common gastrointestinal disorder in the United States. This increase in GERD is not exactly clear but has been attributed to the increasing prevalence of obesity, changing diet, and perhaps the decreasing prevalence of Helicobacter pylori infection. Complications of GERD could be either benign or malignant. Benign complications include erosive esophagitis, bleeding, and peptic strictures. Premalignant and malignant lesions include Barrett’s metaplasia (BE), and esophageal cancer (EA). Metabolic syndrome is considered a state of chronic inflammation and is strongly associated with circulating levels of C-reactive protein (CRP) and fibrinogen. Chronic subclinical inflammation may be one pathophysiological mechanism explaining the increased risk of GERD and complications of GERD associated with metabolic syndrome. Moreover, among patients with BE, increased levels of leptin and insulin resistance are associated with increased risk for EA. A structured weight loss program can lead to resolution of GERD symptoms in the majority of patients.
Keywords
  • Obesity,
  • Metabolic syndrome,
  • Esophagus,
  • Cancer
Publication Date
2016
Editor
Rexford S. Ahima
Publisher
Springer International Publishing
ISBN
978-3-319-11251-0
DOI
https://doi.org/10.1007/978-3-319-11251-0_37
Publisher Statement
This comprehensive reference work edited by one of the leading authorities on obesity presents an up-to-date survey of the current scientific understanding of the metabolic syndrome, as well as an overview of the most significant changes to the field over the past 30 years. This volume is a thorough reference for obesity and the metabolic syndrome and will prove an indispensable resource for clinicians and researchers at levels worldwide.​ The obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on behaviors that lead to obesity, in particular to over consumption of energy-dense food and to sedentary lifestyle. However, obesity is an extremely complex condition with poorly defined pathogenesis. In addition, when combined with other comorbidities such as hypertension and dyslipidemia, obesity often leads to a patient diagnosis of metabolic syndrome, a very troubling condition that has grown, and is continuing to grow, rapidly each year in prevalence worldwide. Metabolic syndrome is a cluster of conditions — increased blood pressure, a high blood sugar level, excess body fat around the waist and abnormal cholesterol levels — that occur together, increasing one’s risk of heart disease, stroke and diabetes. This resource covers the full range of scientific and clinical aspects: epidemiology, genetics, environmental factors, pathophysiology, diseases associated with obesity, and clinical management.
Citation Information
Sravanthi Parasa and Arun Raghav Mahankali Sridhar. "Metabolic Syndrome, GERD, Barrett’s Esophagus" SwitzerlandMetabolic Syndrome: A Comprehensive Textbook (2016) p. 659 - 664
Available at: http://works.bepress.com/sravanthi-parasa/37/