Physiology and Disease is a student led inquiry based class at the Illinois Mathematics and Science Academy, where students design and execute their own experiments and analyze their data based on the evidence they have gathered. Student surveys have also indicated the need for more quantitation in lab experiments. To accommodate all these issues, several changes are being implemented into the course in an effort to allow students to identify the role of the neuronal controls for parameters such as blood pressure and heart rate, and to understand better how they work in concert. A new project (construction of a heart model project) was also included in the curriculum.